mTOR as a central regulator of lifespan and aging

David Papadopoli, Karine Boulay, Lawrence Kazak, +4

F1000Research

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

Masahiro Morita, Julien Prudent, Kaustuv Basu, +14

Molecular Cell

Mitochondrial FunctionMitochondrial DynamicMedicineCell BiologyCell Signaling +1

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

Valentina Gandin, Laìa Masvidal, Laura Hulea, +14

Genome Research

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

Shuo Liu, Simone Hausmann, Scott M. Carlson, +22

Cell

Tumor BiologyMettl13 MethylationMedicineEpigenetic ChangeCancer Genomics +7

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Mélissa Carbonneau, Laurence M. Gagné, Marie‐Eve Lalonde, +15

Nature Communications

Serine Deprivation Enhances Antineoplastic Activity of Biguanides

Simon‐Pierre Gravel, Laura Hulea, Nader Toban, +7

Cancer Research

Serine SynthesisBiochemistryMedicineDiabetesMetabolic Regulation +10

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

Laura Hulea, Simon‐Pierre Gravel, Masahiro Morita, +25

Cell Metabolism

Metabolic NetworkSignal TransductionBiochemistryMetabolic ReprogrammingMedicine +7

Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis

Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, +24

Nature Communications

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

Bianca J. Lee, Jacob A. Boyer, G. Leslie Burnett, +23

Nature Chemical Biology

Tumor BiologyMedicinePharmacologySuppress Tumor GrowthAnti-cancer Agent +4

RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage

Zubaidah M. Ramdzan, Charles Vadnais, Ranjana Pal, +10

PLoS Biology