Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

Marieke Simonis, Petra Klous, Erik Splinter, +5

Nature Genetics

ChromatinChromosome DynamicsNuclear StructureChromatin StructureChromatin Remodeling +11

Quantitative analysis of chromosome conformation capture assays (3C-qPCR)

Hélène Hagège, Petra Klous, Caroline Braem, +5

Nature Protocols

ChromatinGeneticsQuantitative AnalysisMolecular BiologyNucleic Acid Amplification Test +2

CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus

Erik Splinter, Helen Heath, Jurgen Kooren, +5

Genes & Development

Robust 4C-seq data analysis to screen for regulatory DNA interactions

Harmen J.G. van de Werken, Gilad Landan, Sjoerd J.B. Holwerda, +11

Nature Methods

BioinformaticsTranscriptional RegulationDna SequencingRobust 4C-seqNatural Sciences +10

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

Irene Homminga, Rob Pieters, Anton W. Langerak, +21

Cancer Cell

Hematological MalignancyMixed-phenotype Acute LeukemiaImmunologyPotential OncogenesAdult T-cell Leukemia-lymphoma +2

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

Erik Splinter, Elzo de Wit, Elphège P. Nora, +8

Genes & Development

GeneticsGenomic MechanismMolecular BiologyMolecular GeneticsEpigenetics +18

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

Paula J. P. de Vree, Elzo de Wit, Monique van de Heijning, +35

Nature Biotechnology

Long-read SequencingSequencingFunctional GenomicsProximity LigationComprehensive Variant Detection +11

The pluripotent genome in three dimensions is shaped around pluripotency factors

Elzo de Wit, Britta A. M. Bouwman, Yun Zhu, +12

Nature

Pluripotent GenomeMedicineGeneticsGenome StructureGenomic Mechanism +6

4C Technology: Protocols and Data Analysis

Harmen J.G. van de Werken, Paula J. P. de Vree, Erik Splinter, +4

Methods in enzymology on CD-ROM/Methods in enzymology

Data AnalysisEngineeringNetwork Communication ProtocolPhysical LayerProtocols +2

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

Erik Splinter, Helen Heath, Jurgen Kooren, +5

Blood Cells Molecules and Diseases

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingLong-range Chromatin Looping +12