Crystal Structure of the Open Form of Dog Gastric Lipase in Complex with a Phosphonate Inhibitor

Alain Roussel, Nabil Miled, Liliane Berti-Dupuis, +6

Journal of Biological Chemistry

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, +15

Bioorganic & Medicinal Chemistry Letters

Novel Structural ClassMedicinal ChemistryMedicineNatural SciencesRational Drug Design +7

Large-scale production of a therapeutic protein in transgenic tobacco plants: effect of subcellular targeting on quality of a recombinant dog gastric lipase

Véronique Gruber, Patrick Berna, Thierry Arnaud, +23

Molecular Breeding

Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways

Soazig Nénan, Jean‐Michel Planquois, Patrick Berna, +6

International Immunopharmacology

AsthmaInflammationMouse AirwaysAnti-inflammatoryInflammatory Lung Disease +8

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Edwige Lorthiois, Patrick Bernardelli, Fabrice Vergne, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignSelective Pde7 InhibitorsPharmacological Agent +5

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

Patrick Bernardelli, Edwige Lorthiois, Fabrice Vergne, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicine5,8-Disubstituted DerivativesSelective Pde7 InhibitorsRational Drug Design +5

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, +15

Bioorganic & Medicinal Chemistry Letters

Novel Structural ClassMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

Residue Accessibility, Hydrogen Bonding, and Molecular Recognition:  Metal−Chelate Probing of Active Site Histidines in Chymotrypsins

Patrick Berna, Nadir T. Mrabet, Jozef Van Beeumen, +3

Biochemistry

Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial

Sophie Le Lamer, Stéphanie Paradis, Hidayat Rahmouni, +13

Journal of Translational Medicine

Metalloelastase (MMP-12) induced inflammatory response in mice airways: Effects of dexamethasone, rolipram and marimastat

Soazig Nénan, Vincent Lagente, Jean‐Michel Planquois, +4

European Journal of Pharmacology

AsthmaInflammationAnti-inflammatoryInflammatory Lung DiseaseAllergy +9