Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

Masaki Ihara, Kazuhito Noguchi, Toshihiko Saeki, +7

Life Sciences

Molecular PharmacologyEta ReceptorSignal TransductionBiochemistryFunctional Selectivity +10

Clearance of Circulating Endothelin-1 by ETB Receptors in Rats

Takahiro Fukuroda, Tatsuya Fujikawa, Satoshi Ozaki, +3

Biochemical and Biophysical Research Communications

Etb ReceptorsMedicinePhysiologyEndothelial DysfunctionVascular Biology +2

Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

Kiyofumi Ishikawa, M. Ihara, Kazuhito Noguchi, +7

Proceedings of the National Academy of Sciences

Molecular PharmacologyEta-selective AntagonistFunctional SelectivityMedicineVascular Pharmacology +11

Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice

Akio Kanatani, Satoshi Mashiko, Naomi Murai, +10

Endocrinology

An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis

Masaki Ihara, Takahiro Fukuroda, Toshihiko Saeki, +4

Biochemical and Biophysical Research Communications

Molecular PharmacologyBiochemistryMedicineMechanism Of ActionSecondary Metabolite +3

[Ala1,3,11,15]endothelin-1 analogs with ETB agonistic activity

Toshihiko Saeki, Masaki Ihara, Takahiro Fukuroda, +2

Biochemical and Biophysical Research Communications

Etb Agonistic ActivityMolecular PharmacologyMedicinal ChemistryMolecular PhysiologyMedicine +7

Inhibition of biological actions of big endothelin-1 by phosphoramidon

Takahiro Fukuroda, Kazuhito Noguchi, Sonoko Tsuchida, +4

Biochemical and Biophysical Research Communications

Signal TransductionMolecular PhysiologyBig Endothelin-1MedicinePhysiology +6

L-152,804: Orally Active and Selective Neuropeptide Y Y5 Receptor Antagonist

Akio Kanatani, Akane Ishihara, Hisashi Iwaasa, +11

Biochemical and Biophysical Research Communications

Functional SelectivityMedicineNeuropeptide ReceptorNeuropharmacologyPharmacotherapy +5

Endothelin receptor subtypes in human versus rabbit pulmonary arteries

Takahiro Fukuroda, Mutsumi Kobayashi, Satoshi Ozaki, +6

Journal of Applied Physiology

Pulmonary Arterial HypertensionSignal TransductionPulmonary CirculationCardiovascular DiseaseMedicine +12

Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model

Masaru Nishikibe, Sonoko Tsuchida, Megumu Okada, +5

Life Sciences

HypertensionGenetic Hypertensive ModelEndothelin AntagonistMedicinePhysiology +6