Life Sciences · 1992 · 877 citations · 17 references
MedicineMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryPharmacodynamicsLigand BindingPotency OptimizationReceptor PharmacologyEndothelin Receptor Antagonists
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text
Cloning and expression of a cDNA encoding an endothelin receptor
Hiroshi Arai, Seiji Hori, Ichiro Aramori et al. · Nature · 1990 · 2.6K citations
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
Takeshi Sakurai, Masashi Yanagisawa, Yoh Takuwat et al. · Nature · 1990 · 2.4K citations · Full text