Peter H. Dorff

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 412 citations · Full text

A solid phase CBZ chloride equivalent — a new matrix specific linker

James R. Hauske, Peter H. Dorff · Tetrahedron Letters · 1995 · 113 citations

Materials Science, Engineering, Solid-state Chemistry +3

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

Antonia F. Stepan, Kapil Karki, W. Scott McDonald et al. · Journal of Medicinal Chemistry · 2011 · 106 citations · Full text

Chemical Biology, Experimental Pharmacology, Pharmaceutical Chemistry +16

Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives

Mark P. Wentland, George Y. Lesher, Michael Reuman et al. · Journal of Medicinal Chemistry · 1993 · 73 citations · Full text

Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Ivan Efremov, F.F. Vajdos, Kris A. Borzilleri et al. · Journal of Medicinal Chemistry · 2012 · 63 citations · Full text

Pharmaceutical Science, Drug Target, Novel Spiropyrrolidine Inhibitor +21