Aihe Zhou

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau, Hans E. Purkey, A. Hitz et al. · Nature Chemical Biology · 2016 · 268 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Discovery of (<i>S</i>)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1<i>H</i>-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1<i>H</i>)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development

James F. Blake, Michael Burkard, Jocelyn Chan et al. · Journal of Medicinal Chemistry · 2016 · 158 citations · Full text

Medicine, Oncology, Pharmacology +17

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Sue J. Sohn, Kathy Barrett, Anne van Abbema et al. · The Journal of Immunology · 2013 · 126 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors

Emily J. Hanan, Anne van Abbema, Kathy Barrett et al. · Journal of Medicinal Chemistry · 2012 · 90 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Benjamin P. Fauber, Alberto Gobbi, Kirk Robarge et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9