Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

Hae‐Ock Lee, Yourae Hong, Hakki Emre Etlioglu, +34

Nature Genetics

MedicineImmunologyImmune LandscapeColorectal CancerCancer Genomics +8

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Junbin Qian, Siel Olbrecht, Bram Boeckx, +21

Cell Research

Heterogeneous Tumor MicroenvironmentTumor HeterogeneityPan-cancer BlueprintMedicineSingle Cell Sequencing +13

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

Ignasius Joanito, Pratyaksha Wirapati, Nancy Q. Zhao, +49

Nature Genetics

Microbiome confounders and quantitative profiling challengepredicted microbial targets in colorectal cancer development

Raúl Y. Tito, Sara Verbandt, Marta Aguirre Vázquez, +10

Nature Medicine

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy

Amelie Franken, Michel Bila, Aurelie Mechels, +23

Immunity

Cancer ImmunosurveillanceAutoimmune DiseaseAnti-pd-l1 MonotherapyAnti-pd-l1+anti-ctla4 TherapyImmunology +7

Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

Bram Cerulus, Abbas Jariani, Gemma Perez-Samper, +15

eLife

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Daniel Borràs, Sara Verbandt, Markus Außerhofer, +19

Cell Discovery

Recent advances in T-cell receptor repertoire analysis: Bridging the gap with multimodal single-cell RNA sequencing

Sebastiaan Valkiers, Nicky de Vrij, Sofie Gielis, +4

ImmunoInformatics

A Pan-cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling

Junbin Qian, Siel Olbrecht, Bram Boeckx, +21

Biological MicroenvironmentsPathologyComprehensive BlueprintCancer BiologyTumor Biology +19

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Maude Jans, Magdalena Kolata, Gillian Blancke, +15

Nature

Gastrointestinal OncologyColibactin-driven Colon CancerColorectal CancerMedicineCell Biology +2