Concepedia

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy

Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong,

Immunity · 2024 · 99 citations · 46 references

Open access

Concepts

Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyCancer ImmunotherapyCheckpoint Inhibitor TherapyCytotoxic T Lymphocyte ResponsesImmune Checkpoint InhibitorsT Cell ActivationT Cell BiologyCd4 Positive T Cell ResponsesCd4 Positive T CellsCd4 T Cell ActivationCtla-4 InhibitionCytotoxic T-lymphocyte Antigen 4 (Ctla-4) PathwayCytotoxic T-lymphocyte-associated Protein 4 InhibitorsPd-l1 Blockade

References

46

Integrated analysis of multimodal single-cell data

Yuhan Hao, Stephanie Hao, Erica Andersen‐Nissen et al. · Cell · 2021 · 16K citations · Full text

Life Sciences, Bioinformatics, Immunology +17

QuPath: Open source software for digital pathology image analysis

Peter Bankhead, Maurice B. Loughrey, José A. Fernández et al. · Scientific Reports · 2017 · 8.7K citations · Full text

Medicine, Cancer Biology, Pathology +17

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Paul C. Tumeh, Christina L. Harview, Jennifer H. Yearley et al. · Nature · 2014 · 6.6K citations · Full text

Life Sciences, Immunology, Pathology +14

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

Kelly Street, Davide Risso, Russell B. Fletcher et al. · BMC Genomics · 2018 · 3.4K citations · Full text

Life Sciences, Cell Biology, Developmental Biology +17

Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

Barbara Burtness, Kevin J. Harrington, Richard Greil et al. · The Lancet · 2019 · 3.2K citations · Full text

Medicine, Oncology, Cancer Pharmacology +11