Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

Joseph L. Benci, Lexus R. Johnson, Ruth Choa, +14

Cell

Immune EvasionCancer ImmunosurveillanceInterferon Coordinate AdaptiveInnate Immune SystemImmunology +10

CRISPR screen in regulatory T cells reveals modulators of Foxp3

Jessica T. Cortez, Elena Montauti, Eric Shifrut, +22

Nature

GeneticsT-regulatory CellGene EditingGenome EditingGene Expression +6

Engineering the ovarian cycle using in vitro follicle culture

Robin M. Skory, Yuanming Xu, Lonnie D. Shea, +1

Human Reproduction

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Johanna Melo‐Cardenas, Yuanming Xu, Juncheng Wei, +10

Blood

An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity

Yuanming Xu, Lucia Campos Carrascosa, Yik A. Yeung, +41

Cancer Immunology Research

Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction

Jingya Qiu, Bihui Xu, Darwin Ye, +9

Nature Cancer

Immunological MemoryCancer ImmunosurveillanceT Cell DysfunctionImmunologyImmune Checkpoint Inhibitor +9

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Yuanming Xu, Fang Zhao, Quan Qiu, +13

Nature Communications

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationCell Death +23

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

Juncheng Wei, Yanzhi Yuan, Lu Chen, +17

Nature Communications

HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

Juncheng Wei, Lu Chen, Fei Li, +15

The EMBO Journal

Developmental BiologySignal TransductionSignaling PathwayCell RegulationMolecular Regulation +7

The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine–induced ER stress response

Yuanming Xu, Johanna Melo‐Cardenas, Yana Zhang, +9

JCI Insight

Immune RegulationImmunologyImmune DysregulationInflammationTranscriptional Regulation +19