Jason Stavropoulos

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Cherrie K. Donawho, Yan Luo, Yanping Luo et al. · Clinical Cancer Research · 2007 · 773 citations · Full text

Medicine, Oncology, Pharmacology +15

A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs <i>In vitro</i> and <i>In vivo</i>

Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch et al. · Cancer Research · 2006 · 146 citations

Medicine, Oncology, Pharmacology +10

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

Yunsong Tong, Jennifer J. Bouska, Eric F. Johnson et al. · Journal of Medicinal Chemistry · 2009 · 108 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.

Joann P. Palma, Luis E. Rodrı́guez, Velitchka Bontcheva-Diaz et al. · PubMed · 2008 · 56 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

Jieyi Wang, Lora A. Tucker, Jason Stavropoulos et al. · Proceedings of the National Academy of Sciences · 2008 · 36 citations · Full text

Medicine, Oncology, Pharmacology +13