ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Cherrie K. Donawho, Yan Luo, Yanping Luo, +34

Clinical Cancer Research

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

Cheol‐Min Park, Milan Bruncko, Jessica Adickes, +16

Journal of Medicinal Chemistry

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models

Alex R. Shoemaker, Michael J. Mitten, Jessica Adickes, +15

Clinical Cancer Research

Discovery of<i>N</i>-(4-(3-Amino-1<i>H</i>-indazol-4-yl)phenyl)-<i>N</i>‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Yujia Dai, Kresna Hartandi, Zhiqin Ji, +25

Journal of Medicinal Chemistry

Compound 17PDrug TargetChemoprevention StrategyKinase InhibitorsPharmacotherapy +18

Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors

Yujia Dai, Yan Guo, Robin R. Frey, +24

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyPharmaceutical ChemistryThienopyrimidine UreasTumor Biology +15

A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs <i>In vitro</i> and <i>In vivo</i>

Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch, +24

Cancer Research

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Michael Wendt, Shen Wang, Aaron Kunzer, +19

Journal of Medicinal Chemistry

3,5-Bis(trifluoromethyl)pyrazoles:  A Novel Class of NFAT Transcription Factor Regulator

Stevan W. Djurić, Nwe Y. BaMaung, Anwer Basha, +26

Journal of Medicinal Chemistry

Molecular RegulationImmunologyPharmacotherapyChemical BiologyPharmaceutical Chemistry +16

Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression

Yung‐Wu Chen, Morey L. Smith, Michael P. Sheets, +14

Journal of Cardiovascular Pharmacology

Systemic ImmunosuppressionVivo Half-lifeImmunologyPotent Anti-proliferative ActivitySirolimus Apparent +14

ABT-263 and rapamycin act cooperatively to kill lymphoma cells <i>in vitro</i> and <i>in vivo</i>

Scott Ackler, Xiao Yu, Michael J. Mitten, +13

Molecular Cancer Therapeutics