A molecular single-cell lung atlas of lethal COVID-19

Johannes C. Melms, Jana Biermann, Huachao Huang, +41

Nature

Lethal Covid-19Respiratory InfectionCovid-19Infectious Respiratory Disease

Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, +75

Nature

Neuro-oncologyMedicineTherapeutic ImplicationsHigh-grade GliomasCell Biology +3

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Chris J. Frangieh, Johannes C. Melms, Pratiksha I. Thakore, +18

Nature Genetics

Tumor BiologyImmune EvasionCancer Immune EvasionOncologyCancer Immunosurveillance +9

Dissecting the treatment-naive ecosystem of human melanoma brain metastasis

Jana Biermann, Johannes C. Melms, Amit Dipak Amin, +56

Cell

Neuro-oncologyMelanomaTreatment-naive EcosystemNeuroscienceMedicine +2

The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity

Patricia Ho, Johannes C. Melms, Meri Rogava, +30

Cancer Cell

Cancer ImmunosurveillanceCd58-cd2 AxisImmunologyTumor ImmunityImmunologic Mechanism +9

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors

Shakti Ramkissoon, Pratiti Bandopadhayay, Jaeho Hwang, +33

Neuro-Oncology

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

Giuseppe Leuzzi, Alessandro Vasciaveo, Angelo Taglialatela, +30

Cell

Tumor BiologyCancer ImmunosurveillancePd-l1 ExpressionMedicineImmunology +8

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, +53

Nature Communications

Molecular NeuroscienceDevelopmental BiologyCell RegulationMedicineCell Interaction +6

The Enzymatic Synthesis of Ribonucleic Acid in Animal Tissue

J. Fürth, Patricia Ho

Journal of Biological Chemistry

BiosynthesisBiochemistryNatural SciencesEnzymatic SynthesisBiological Synthesis +3

Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens

Yiping Wang, Joy Linyue Fan, Johannes C. Melms, +22

Nature Genetics

BioinformaticsLong-read SequencingSequencingMultimodal Single-cellSingle Cell Sequencing +11