Ignacio Moraleda

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

Li Wang, Gerard Esteban, Masaki Ojima et al. · European Journal of Medicinal Chemistry · 2014 · 137 citations · Full text

Medicinal Chemistry, Neurodegenerative Diseases, Alzheimer's Disease +12

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

Óscar M. Bautista‐Aguilera, Gerard Esteban, Irene Bolea et al. · European Journal of Medicinal Chemistry · 2014 · 136 citations · Full text

Molecular Pharmacology, Neurodegenerative Diseases, Qsar Analysis +11

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase

Ehab D. AlFadly, Perihan A. Elzahhar, Anna Tramarin et al. · European Journal of Medicinal Chemistry · 2019 · 101 citations · Full text

Alzheimer's Disease, Medicine, Dementia +11

Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H₃R Antagonism for Neurodegenerative Diseases

Óscar M. Bautista‐Aguilera, Stefanie Hagenow, Alejandra Palomino‐Antolín et al. · Angewandte Chemie International Edition · 2017 · 100 citations

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification

Ricardo Caballero, Pablo Dolz-Gaitón, Ricardo Gómez et al. · Proceedings of the National Academy of Sciences · 2010 · 88 citations · Full text

Polyamine-induced Rectification, Cardiac Muscle, Andersen Syndrome +19