Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase

Ehab D. AlFadly, Perihan A. Elzahhar, Anna Tramarin, +15

European Journal of Medicinal Chemistry

Alzheimer's DiseaseMedicineDementiaVascular DementiaNeuropharmacology +9

Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases

Perihan A. Elzahhar, Shrouk M. Abd El Wahab, Mohamed Elagawany, +12

European Journal of Medicinal Chemistry

Tumor-associated Carbonic AnhydrasesMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies

Nayera W. Hassan, Manal N. Saudi, Yasser S. Abdel‐Ghany, +6

Bioorganic Chemistry

Anti-tubercular AgentsHealth SciencesMedicineNovel PyrazinePharmacological Agent +8

Anti-leishmanial click modifiable thiosemicarbazones: Design, synthesis, biological evaluation and in silico studies

Mohamed G. Temraz, Perihan A. Elzahhar, Alaa El‐Din A. Bekhit, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryAntiparasitic AgentNatural Sciences +8

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones

Perihan A. Elzahhar, Rana Alaaeddine, Tamer M. Ibrahim, +11

European Journal of Medicinal Chemistry

InflammationDrug TargetingAnti-inflammatoryInflammatory TargetsNovel Therapy +8

Design, Synthesis and Biological Screening of Some Pyridinylpyrazole and Pyridinylisoxazole Derivatives as Potential Anti-inflammatory, Analgesic, Antipyretic and Antimicrobial Agents

Soad A. El-Hawash, Raafat Soliman, Amal Youssef, +5

Medicinal Chemistry

PharmacotherapyRat-tail Withdrawal TechniqueGram Negative BacteriaAntimicrobial ChemotherapyPotential Anti-inflammatory +17

Insights on the in-vitro binding interaction between donepezil and bovine serum albumin

Reem N. El Gammal, Heba Elmansi, Ali A. El‐Emam, +4

BMC Chemistry

The Emerging Role of COX-2, 15-LOX and PPARγ in Metabolic Diseases and Cancer: An Introduction to Novel Multi-target Directed Ligands (MTDLs)

Rana Alaaeddine, Perihan A. Elzahhar, Ibrahim AlZaim, +3

Current Medicinal Chemistry

15-Lox ActivitiesArachidonic Acid MetabolismLipid PeroxidationMetabolic DiseasesMetabolic Remodeling +20

Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies

Nayera W. Hassan, Ahmed Sabt, Maryam A.Z. El-Attar, +6

European Journal of Medicinal Chemistry

Combinatorial ChemistryBiochemistryMedicineComputational StudiesNew Coumarin-1,2,3-triazoles +4

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing

Perihan A. Elzahhar, Hisham A. Nematalla, Houssam Al-Koussa, +3

Journal of Medicinal Chemistry