Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel, +44

Nature Cell Biology

InflammationCell AutophagySignal TransductionHeme HomeostasisIron Metabolism +11

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

James Palacino, Susanne E. Swalley, Cheng Song, +37

Nature Chemical Biology

Transcriptional RegulationGeneticsGene RegulationGene ExpressionMedicine +5

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Jessica N. Spradlin, Xirui Hu, Carl C. Ward, +15

Nature Chemical Biology

Drug TargetingHealth SciencesBiochemistryBioconjugationTumor Targeting +7

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Carl C. Ward, Jordan I. Kleinman, Scott M. Brittain, +9

ACS Chemical Biology

Protein FunctionBiochemistryBiomolecular ToolProtein FoldingDrug Discovery +11

Size-Specific Ligands for RNA Hairpin Loops

Jason R. Thomas, Xianjun Liu, Paul J. Hergenrother

Journal of the American Chemical Society

Chemical BiologyMedicinal ChemistryBiochemistryNatural SciencesSmall Molecules +10

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Eduardo Domínguez, Andrea Galmozzi, Jae Won Chang, +13

Nature Chemical Biology

ObesityMetabolic SyndromeBody CompositionMetabolic DisorderDiabetes +10

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti‐Cancer Properties

Philipp Krastel, Silvio Roggo, Markus Schirle, +19

Angewandte Chemie International Edition

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Nathan T. Ross, Felix Lohmann, Seth Carbonneau, +39

Nature Chemical Biology

Transcriptional RegulationMedicineCancer Cell BiologyDruggable NodeCpsf3-dependent Pre-mrna Processing +7

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Martin Schröder, Martin Renatus, Xiaoyou Liang, +37

Nature Communications

Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

Joel W. Thompson, Jane Nagel, Sjouke Hoving, +6

Journal of Biological Chemistry