Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Heiko Johnen, Shu Lin, Támara Kuffner, +21

Nature Medicine

ObesityTumor BiologyWeight LossTumor-induced AnorexiaMedicine +7

The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

Samuel N. Breit, Heiko Johnen, Andrew D. Cook, +12

Growth Factors

ImmunologyPathologyCancer BiologyTumor BiologyInflammation +14

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

Laurence Macia, Vicky Wang-Wei Tsai, Amy Nguyen, +8

PLoS ONE

NutritionObesogenic DietsImmunologyFood IntakeGlucose Homeostasis +20

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

Vicky Wang-Wei Tsai, Laurence Macia, Heiko Johnen, +14

PLoS ONE

The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome

Asne R. Bauskin, David A. Brown, Simon Junankar, +16

Cancer Research

Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: A potential marker of erosive joint destruction

David A. Brown, John J. Moore, Heiko Johnen, +8

Arthritis & Rheumatism

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis

Heiko Johnen, Támara Kuffner, David A. Brown, +3

Cardiovascular Pathology

InflammationCytokineImmune Cell DevelopmentCell SignalingApoe−/− Mice +9

Gadd45g Is Essential for Primary Sex Determination, Male Fertility and Testis Development

Heiko Johnen, Laura González-Silva, Laura Carramolino, +3

PLoS ONE

SpermatogenesisFertilityGeneticsReproductive BiologyEmbryology +18

Long-term tumor growth suppression in mice immunized with naked DNA of the human tumor antigen mucin (MUC1)

Heiko Johnen, Hagen Kulbe, Gabriele Pecher

Cancer Immunology Immunotherapy

Tumor BiologyOncogenic AgentMedicineImmunologyNaked Dna +6

The Second Messenger Binding Site of Inositol 1,4,5-Trisphosphate 3-Kinase Is Centered in the Catalytic Domain and Related to the Inositol Trisphosphate Receptor Site

Uwe Bertsch, Christina Deschermeier, Werner Fanick, +6

Journal of Biological Chemistry