Activation of the ATPase Activity of Hsp90 by the Stress-Regulated Cochaperone Aha1

Barry Panaretou, Giuliano Siligardi, Philippe Meyer, +13

Molecular Cell

Atpase ActivityReductive StressSignal TransductionCellular EnzymologyBiochemistry +8

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

Udai Banerji, Anne O’Donnell, Michelle Scurr, +12

Journal of Clinical Oncology

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryHsp90 InhibitorsNatural Sciences +8

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone

Paul A. Clarke, Isabelle Hostein, Udai Banerji, +5

Oncogene

Signal TransductionMedicineColorectal CancerCancer GenomicsHsp90 Molecular Chaperone +6

Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

Alison Maloney, Paul A. Clarke, Søren Naaby‐Hansen, +18

Cancer Research

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

James P. O’Connell, John Porter, Boris Kroeplien, +15

Nature Communications

<i>In vitro</i> Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

Swee Y. Sharp, Kathy Boxall, Martin Rowlands, +19

Cancer Research

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

Anthony Shock, Linda C. Burkly, Ian Wakefield, +20

Arthritis Research & Therapy

WNT3A‐loaded exosomes enable cartilage repair

B.L. Thomas, S. Eldridge, Babak Nosrati, +13

Journal of Extracellular Vesicles

Tissue EngineeringRegenerative MedicineExtracellular VesiclesMusculoskeletal ResearchEngineering +13

Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase

John Porter, Simon Lumb, Fabien Lecomte, +11

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryC-met KinaseNovel SeriesBiochemistry +9