Melissa C. Holt

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

Frederick Cohen, James B. Aggen, Logan D. Andrews et al. · ChemMedChem · 2019 · 75 citations

Antibiotic Adjuvant, Cardiovascular Pharmacology, Pharmacotherapy +19

Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated

Neil B. Varshneya, Sherif H. Hassanien, Melissa C. Holt et al. · Biochemical Pharmacology · 2021 · 54 citations · Full text

Opioid Epidemic, Fentanyl, Addiction +8

Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

Melissa C. Holt, Zahra Assar, Reza Beheshti Zavareh et al. · Biochemistry · 2018 · 39 citations · Full text

Aldo-keto Reductase, Molecular Biology, Plp Site +23

Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors

Daniel R. Goldberg, Stéphane De Lombaert, Robert J. Aiello et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 33 citations · Full text

Spirocyclic Proline, Biochemistry, Medicine +5

Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE₁ Series EP₄ Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE₁ Analog (KMN-159) as a Potent EP₄ Agonist

Stephen D. Barrett, Melissa C. Holt, James B. Kramer et al. · Journal of Medicinal Chemistry · 2019 · 33 citations · Full text