Effect of polyamines on stabilization of molecular complexes in thylakoid membranes of osmotically stressed oat leaves

R. T. Besford, Christine M. Richardson, J. Lourdes Campos, +1

Planta

EngineeringPlant StressBiochemistryBotanyNatural Sciences +8

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

Roland W. Bürli, Christopher A. Luckhurst, Omar Aziz, +27

Journal of Medicinal Chemistry

Aldo-keto ReductaseMolecular BiologyChemical BiologyPotential TherapyPharmaceutical Chemistry +17

The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Murray J. B. Brown, Paul S. Carter, Ashley Fenwick, +11

Bioorganic & Medicinal Chemistry Letters

Natural Product SynthesisAntibioticsMedicineSynthetic AnaloguesSelective Inhibitors +8

Identification of Novel Adenosine A_2A Receptor Antagonists by Virtual Screening

Christopher J. Langmead, Stephen P. Andrews, Miles Congreve, +8

Journal of Medicinal Chemistry

Enabled Homology ModelsDrug TargetPharmacotherapyMolecular PharmacologyMedicinal Chemistry +14

Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets

Nicolas Baurin, Fareed Aboul‐ela, Xavier Barril, +8

Journal of Chemical Information and Computer Sciences

Drug TargetStructural BioinformaticsBiomolecular Structure PredictionMolecular FragmentsMolecular Biology +17

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Andrew Potter, Victoria Oldfield, Claire L. Nunns, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryNatural SciencesMedicine +7

Structure-guided design of α-amino acid-derived Pin1 inhibitors

Andrew Potter, Stuart Ray, Louisa Gueritz, +12

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMolecular PharmacologyMedicinal ChemistryMedicineRational Drug Design +4

Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A

Murray J. B. Brown, Lucy Mensah, Michael L. Doyle, +6

Biochemistry

Crystal StructureBioorganic ChemistryMolecular BiologyChemical BiologyPharmaceutical Chemistry +21

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR

Christine M. Richardson, D.S. Williamson, Martin J. Parratt, +10

Bioorganic & Medicinal Chemistry Letters

Drug TargetMedicineRational Drug DesignNovel Cdk2 InhibitorsPharmacotherapy +6

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2

D.S. Williamson, Martin J. Parratt, Justin Bower, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +8