Christopher J. Langmead

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Guillaume Lebon, Tony Warne, Patricia C. Edwards et al. · Nature · 2011 · 871 citations · Full text

Molecular Pharmacology, Signal Transduction, Molecular Physiology +10

Discovery of 1,2,4-Triazine Derivatives as Adenosine A_2A Antagonists using Structure Based Drug Design

Miles Congreve, Stephen P. Andrews, A.S. Dore et al. · Journal of Medicinal Chemistry · 2012 · 301 citations · Full text

Combinatorial Chemistry, Compound 4K, Pharmacotherapy +16

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

Xin Zhang, Matthew J. Belousoff, Peishen Zhao et al. · Molecular Cell · 2020 · 212 citations · Full text

Signal Transduction, Biochemistry, G Protein-coupled Receptor +7

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery

N.J. Robertson, Ali Jazayeri, James C. Errey et al. · Neuropharmacology · 2010 · 158 citations

Drug Target, Biochemistry, G Protein-coupled Receptor +5

Characterisation of the binding of [³H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor

Christopher J. Langmead, Jeffrey C. Jerman, Stephen Brough et al. · British Journal of Pharmacology · 2004 · 136 citations · Full text

Molecular Pharmacology, Membrane Formats, Biochemistry +13