Ronald A. Forsch

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.

G R Westerhof, Jan H. Schornagel, Ietje Kathmann et al. · Molecular Pharmacology · 1995 · 205 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Structural features of 4-amino antifolates required for substrate activity with mammalian folylpolyglutamate synthetase.

R G Moran, Paul D. Colman, A. Rosowsky et al. · Molecular Pharmacology · 1985 · 79 citations

Life Sciences, Biochemistry, Pharmacology +17

Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium

Ronald A. Forsch, Sherry F. Queener, A. Rosowsky · Bioorganic & Medicinal Chemistry Letters · 2004 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Design, Synthesis, and Antifolate Activity of New Analogues of Piritrexim and Other Diaminopyrimidine Dihydrofolate Reductase Inhibitors with ω-Carboxyalkoxy or ω-Carboxy-1-alkynyl Substitution in the Side Chain

David C. Chan, Hongning Fu, Ronald A. Forsch et al. · Journal of Medicinal Chemistry · 2005 · 57 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Methotrexate analogs. 14. Synthesis of new .gamma.-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents

A. Rosowsky, Ronald A. Forsch, Jack R. Uren et al. · Journal of Medicinal Chemistry · 1981 · 56 citations

Medicine, Medicinal Chemistry, Pharmacology +10