Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Milan Bruncko, Thorsten Oost, Barbara Belli, +19

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyPharmaceutical ChemistryCompound 2Tumor Biology +17

A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs <i>In vitro</i> and <i>In vivo</i>

Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch, +24

Cancer Research

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Michael Wendt, Shen Wang, Aaron Kunzer, +19

Journal of Medicinal Chemistry

Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of <i>N</i>-Phenyl Amide 6-Substitution

Michael Wendt, Todd W. Rockway, Andrew Geyer, +8

Journal of Medicinal Chemistry

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

Le Wang, John K. Pratt, Todd Soltwedel, +30

Journal of Medicinal Chemistry

Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases

William J. McClellan, Yujia Dai, Cele Abad‐Zapatero, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNatural SciencesMedicineMolecular BiologyAurora Kinases +4

Reduction of nanoparticle exposure to welding aerosols by modification of the ventilation system in a workplace

Myong‐Hwa Lee, William J. McClellan, Joe Candela, +2

Journal of Nanoparticle Research

Materials ScienceNanoparticle ExposureChemical EngineeringEngineeringIndoor Aerosol +8

Conformationally defined adrenergic agents. 1. Design and synthesis of novel .alpha.2-selective adrenergic agents: electrostatic repulsion based conformational prototypes

John F. DeBernardis, Daniel J. Kerkman, Martin Winn, +5

Journal of Medicinal Chemistry

Combinatorial ChemistryAdrenergic AgentsElectrostatic Repulsion HypothesisOrganic ChemistryPeptide Science +16

A simple, high-yielding method for the methylenation of catechols

Robert E. Zelle, William J. McClellan

Tetrahedron Letters

Chemical EngineeringEngineeringSustainable SynthesisOrganic ChemistryChemistry +2

Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors

Michael Wendt, Andrew Geyer, William J. McClellan, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineRational Drug DesignMechanism Of Action +5