Astrid Grottke

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

Astrid Grottke, Florian Ewald, Tobias Lange et al. · PLoS ONE · 2016 · 99 citations · Full text

Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

Florian Ewald, Nicole Grabinski, Astrid Grottke et al. · International Journal of Cancer · 2013 · 86 citations · Full text

Chemoprevention Strategy, Immunology, Pathology +19

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

Florian Ewald, Dominik Nörz, Astrid Grottke et al. · Investigational New Drugs · 2014 · 59 citations

Dual Inhibition, Medicine, Biliary Cancer +5

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

Marina Holler, Astrid Grottke, Katharina Mueck et al. · PLoS ONE · 2016 · 50 citations · Full text

Akt Activity, Dna Double-strand Breaks, Mtorc1 Inhibitor Rapamycin +17

ErbB2 signaling activates the Hedgehog pathway via PI3K–Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts

Maxim Kebenko, Astrid Drenckhan, Stephanie J. Gros et al. · Cellular Signalling · 2014 · 47 citations

Cancer Research, Oncology, Esophageal Cancer +12