COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

Bianca T. Hofmann, Laura Schlüter, Philipp F. Lange, +15

Molecular Cancer

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells

Nicole Grabinski, Florian Ewald, Bianca T. Hofmann, +4

Molecular Cancer

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

Astrid Grottke, Florian Ewald, Tobias Lange, +9

PLoS ONE

Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

Florian Ewald, Nicole Grabinski, Astrid Grottke, +10

International Journal of Cancer

Chemoprevention StrategyImmunologyPathologyCholangiopathiesMtor Treatment +17

Circulating tumor cells as liquid biomarker for high HCC recurrence risk after curative liver resection

Johann von Felden, Kornelius Schulze, Till Krech, +6

Oncotarget

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

Florian Ewald, Dominik Nörz, Astrid Grottke, +3

Investigational New Drugs

Dual InhibitionMedicineBiliary CancerPathologyCancer Biology +3

Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells

Nicole Grabinski, Florian Ewald

Investigational New Drugs

Breast OncologyMedicinePharmacologyErbb Receptor PhosphorylationCell Viability +7

ErbB2 signaling activates the Hedgehog pathway via PI3K–Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts

Maxim Kebenko, Astrid Drenckhan, Stephanie J. Gros, +9

Cellular Signalling

Cancer ResearchOncologyEsophageal CancerHedgehog PathwayMedicine +10

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

Florian Ewald, Dominik Nörz, Astrid Grottke, +5

Journal of Cancer

ImmunologyCell DeathCancer BiologyTumor BiologyOncology +16

Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP)

Doan Duy Hai Tran, Alexandra Koch, Aldrige Bernardus Allister, +5

Cellular Signalling

OncologyMedicineApoptosisCell DeathPathology +5