Brian P. Stupi

Improved nucleotide selectivity and termination of 3′-OH unblocked reversible terminators by molecular tuning of 2-nitrobenzyl alkylated HOMedU triphosphates

Vladislav A. Litosh, Weidong Wu, Brian P. Stupi et al. · Nucleic Acids Research · 2011 · 46 citations · Full text

Engineering, Molecular Biology, Chemical Biology +18

Termination of DNA synthesis by N6 -alkylated, not 3′- O -alkylated, photocleavable 2′-deoxyadenosine triphosphates

Weidong Wu, Brian P. Stupi, Vladislav A. Litosh et al. · Nucleic Acids Research · 2007 · 43 citations · Full text

Stereochemistry of Benzylic Carbon Substitution Coupled with Ring Modification of 2‐Nitrobenzyl Groups as Key Determinants for Fast‐Cleaving Reversible Terminators

Brian P. Stupi, Hong Li, Jinchun Wang et al. · Angewandte Chemie International Edition · 2012 · 33 citations · Full text

Bioorganic Chemistry, Engineering, Molecular Biology +21

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region

Gary D. Probst, Simeon Bowers, Jennifer M. Sealy et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · Full text

Structure–activity Relationship, Medicinal Chemistry, Aryl Region +9

Rapid incorporation kinetics and improved fidelity of a novel class of 3′-OH unblocked reversible terminators

Andrew F. Gardner, Jinchun Wang, Weidong Wu et al. · Nucleic Acids Research · 2012 · 24 citations · Full text

Engineering, Molecular Biology, Analytical Ultracentrifugation +23