Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

Jason Carte, Ruiying Wang, Hong Li, +2

Genes & Development

Crispr Repeat ElementMolecular BiologyMolecular GeneticsCrispr LociOff-target Effect +15

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

Jianjun Wu, Wenwei Li, Yaming Shao, +13

Cell Host & Microbe

Molecular VirologyHerpesvirus Virion ProteinNatural SciencesPathogenesisMolecular Biology +6

Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system

Joshua R. Elmore, Nolan F. Sheppard, Nancy Ramia, +4

Genes & Development

Crispr RnaCrispr-cas SystemsGeneticsMedicineNatural Sciences +12

Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display

Aimee Payne, Ken Ishii, Stephen Kacir, +7

Journal of Clinical Investigation

ImmunodeficienciesImmunologyPathologyAntigen ProcessingDermatology +18

Atomic Structure of Li₂MnO₃ after Partial Delithiation and Re‐Lithiation

Rui Wang, Xiaoqing He, Lunhua He, +5

Advanced Energy Materials

EngineeringChemistryInorganic MaterialLi 2Atomic Structure +17

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, +20

Nature Biotechnology

Primary CellsGenome InstabilityHigh-yield Genome EngineeringEngineeringSmall-molecule Cocktails +9

Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways

Long Xiao, Mengdan Zhong, Yu Huang, +9

Aging

Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage

Ruiying Wang, G. Preamplume, Michael P. Terns, +2

Structure

Crispr RnasEngineeringRna Structure PredictionRna BiologyMolecular Biology +7

Molecular Basis of Box C/D RNA-Protein Interactions

T. Moore, Yanming Zhang, Márcia O. Fenley, +1

Structure

Natural SciencesRna Binding ProteinsRna Structure PredictionRna BiologyMolecular Biology +2

Crystal Structure of a Cbf5-Nop10-Gar1 Complex and Implications in RNA-Guided Pseudouridylation and Dyskeratosis Congenita

Rumana Rashid, Bo Liang, Daniel L. Baker, +6

Molecular Cell

Crystal StructureCbf5-nop10-gar1 ComplexRna-guided PseudouridylationRna Structure PredictionProtein X-ray Crystallography +4