Yanhe Wen

MEN1 mutations mediate clinical resistance to menin inhibition

Florian Perner, Eytan M. Stein, Daniela V. Wenge et al. · Nature · 2023 · 243 citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

The menin-MLL1 interaction is a molecular dependency in <i>NUP98</i>-rearranged AML

Emily Heikamp, Jill A. Henrich, Florian Perner et al. · Blood · 2021 · 141 citations · Full text

Life Sciences, Molecular Biology, Oncology +13

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of <i>KMT2A</i>-r and <i>NPM1c</i> AML

Wallace Bourgeois, Jevon Cutler, Brandon J. Aubrey et al. · Blood · 2023 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity

James B. Shaum, Miquel Muñoz i Ordoño, Erica A. Steen et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024 · 22 citations · Full text

Life Sciences, Biochemistry, Chemistry +16

S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A

Florian Perner, Homa Rahnamoun, Daniela V. Wenge et al. · HemaSphere · 2023 · 13 citations · Full text

Medicine, Molecular Biology, Oncology +17