Concepedia

MEN1 mutations mediate clinical resistance to menin inhibition

Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton,

Nature · 2023 · 243 citations · 21 references

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21

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis

Akihiko Yokoyama, Tim C. P. Somervaille, Kevin S. Smith et al. · Cell · 2005 · 670 citations · Full text

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Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the Hoxc8 Locus

Christina M. Hughes, Orit Rozenblatt–Rosen, Thomas A. Milne et al. · Molecular Cell · 2004 · 635 citations · Full text

, , +15

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

Zaneta Nikolovska‐Coleska, Renxiao Wang, Xueliang Fang et al. · Analytical Biochemistry · 2004 · 557 citations

, , +15

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

Akihiko Yokoyama, Michael L. Cleary · Cancer Cell · 2008 · 542 citations · Full text

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The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia

Ghayas C. Issa, Ibrahim Aldoss, John F. DiPersio et al. · Nature · 2023 · 468 citations · Full text

, , +13