Quentin Spillier

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Marie Solvay, Simon Klaessens, Luc Pilotte et al. · Journal for ImmunoTherapy of Cancer · 2023 · 81 citations · Full text

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH)

Séverine Ravez, Cyril Corbet, Quentin Spillier et al. · Journal of Medicinal Chemistry · 2017 · 65 citations · Full text

Drug Target, α-Ketothioamide Derivatives, Peptide Science +22

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Quentin Spillier, Didier Vertommen, Séverine Ravez et al. · Scientific Reports · 2019 · 58 citations · Full text

The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway

Robert S. Banh, Esther Kim, Quentin Spillier et al. · Nature · 2021 · 52 citations · Full text

Biosynthesis, Aldehyde Dehydrogenase, Biochemistry +4

Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)

Quentin Spillier, Séverine Ravez, Judith E. Unterlass et al. · Pharmaceuticals · 2020 · 23 citations · Full text