Enaminones: versatile intermediates for natural product synthesis

Joseph P. Michael, Charles B. de Koning, David Gravestock, +7

Pure and Applied Chemistry

EngineeringOrganic ChemistryNatural Product SynthesisEnantioselective SynthesisBiomolecular Engineering +1

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

Moira L. Bode, David Gravestock, Simon S. Moleele, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineAntiviral Drug DevelopmentAntiviral DrugHiv +3

Covalent‐Allosteric Kinase Inhibitors

Jörn Weisner, Rajesh Gontla, Leandi Van Der Westhuizen, +12

Angewandte Chemie International Edition

Molecular DockingMolecular PharmacologyMedicinal ChemistryDrug TargetDistinct Kinase Conformations +13

Metathesis Reactions for the Synthesis of Ring-Fused Carbazoles

Stephen C. Pelly, Christopher J. Parkinson, Willem A. L. van Otterlo, +1

The Journal of Organic Chemistry

The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth

Simone Pellegrino, Mélanie Meyer, Christiane Zorbas, +9

Structure

BiosynthesisBiochemistryAmaryllidaceae Alkaloid HaemanthamineMedicineNatural Sciences +8

In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives

Nikolai M. Evdokimov, Delphine Lamoral‐Theys, Véronique Mathieu, +8

Bioorganic & Medicinal Chemistry

Lycorine DerivativesBiochemistryMedicineDrug DiscoveryCytostatic Agent +4

Stereoselective Syntheses of the 2-Isopropenyl-2,3-dihydrobenzofuran Nucleus:  Potential Chiral Building Blocks for the Syntheses of Tremetone, Hydroxytremetone, and Rotenone

Stephen C. Pelly, Sameshnee Govender, Manuel A. Fernandes, +2

The Journal of Organic Chemistry

Catalytic Palladium-mediated ReactionEngineeringBiochemistryNatural Sciences2-Isopropenyl-2,3-dihydrobenzofuran Nucleus +12

Bulbispermine: A Crinine‐Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity toward Apoptosis‐Resistant Glioma Cells

Giovanni Luchetti, Robert K. Johnston, Véronique Mathieu, +13

ChemMedChem

Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

Mohammad Hassam, Adriaan E. Basson, Dennis C. Liotta, +3

ACS Medicinal Chemistry Letters

Medicinal ChemistryAntiviral CompoundBiochemistryHydrophobic PocketsNatural Sciences +13

C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: Retention of activity of highly lipophilic analogues against cancer cells

Ramesh Dasari, Laetitia Moreno Y Banuls, Marco Masi, +7

Bioorganic & Medicinal Chemistry Letters

BiochemistryC2-ether DerivativesMedicineHerb-drug InteractionAmaryllidaceae Alkaloid Lycorine +5