Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Emanuela Santini, Thu N. Huynh, Andrew F. MacAskill, +5

Nature

Developmental Cognitive NeuroscienceSyndromic AutismNeurolinguisticsExaggerated TranslationAutism +5

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

Aditi Bhattacharya, Hanoch Kaphzan, Amanda Alvarez-Dieppa, +3

Neuron

Knockout MouseSynaptic PlasticityMolecular NeuroscienceMendelian DisorderGenetic Removal +13

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Keiichi Inoue, Joanne Rispoli, Hanoch Kaphzan, +5

Molecular Neurodegeneration

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, +3

Cell Reports

Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology

Tsuyoshi Udagawa, Natalie G. Farny, Mira Jakovcevski, +13

Nature Medicine

Mendelian DisorderGenetic DisorderGeneticsFragile X SpectrumDegenerative Disease +4

Alterations in Intrinsic Membrane Properties and the Axon Initial Segment in a Mouse Model of Angelman Syndrome

Hanoch Kaphzan, Shelly A. Buffington, Joo In Jung, +2

Journal of Neuroscience

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties

Vijendra Sharma, Hadile Ounallah-Saad, Darpan Chakraborty, +8

Journal of Neuroscience

Neuromodulation of Axon Terminals

Darpan Chakraborty, Dennis Q. Truong, Marom Bikson, +1

Cerebral Cortex

Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc

Dev Sharan Sams, Stefano Nardone, Dmitriy Getselter, +6

Cell Reports

NeuropsychologyDevelopmental Cognitive NeuroscienceExperience-dependent Gene RegulationNeurotransmissionStructural Plasticity +25

Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

Hanoch Kaphzan, Pepe J. Hernandez, Joo In Jung, +5

Biological Psychiatry

Neurobiological MechanismNeuropsychologyPsychiatryMedicineNeurobiological Factor +11