Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Loren Lasko, Clarissa G. Jakob, Rohinton Edalji, +36

Nature

Lineage-specific TumoursMedicineImmune Checkpoint InhibitorAnti-cancer AgentTumor Suppressor +6

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

Sarah J. Fentress, Michael S. Behnke, Ildikò Rita Dunay, +12

Cell Host & Microbe

InflammationSignal TransductionPathogenesisImmunologyCell Death +7

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Julie A. Frearson, Stephen Brand, Stuart P. McElroy, +23

Nature

SleepSleep DisorderN-myristoyltransferase InhibitorsPharmacologyPharmacotherapy +3

ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER

Aubrey V. Weigel, Chi‐Lun Chang, Gleb Shtengel, +10

Cell

Golgi ApparatusProtein FunctionEngineeringProtein SecretionEr-to-golgi Protein Delivery +8

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms

Masoud Vedadi, J. Lew, J.D. Artz, +28

Molecular and Biochemical Parasitology

BiologyRelated Apicomplexan OrganismsGenome-scale Protein ExpressionMedicineNatural Sciences +8

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

Chao Xu, Chuanbing Bian, Wei Yang, +11

Proceedings of the National Academy of Sciences

Histone ModificationsHistone MarksStructural BioinformaticsEpigenetic ChangeMolecular Regulation +19

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

Hui Ouyang, Yousuf Ali, Mani Ravichandran, +6

Journal of Biological Chemistry

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

Hong Wu, Hong Zeng, Robert Lam, +7

PLoS ONE

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Christina K. Baumgartner, Hakimeh Ebrahimi-Nik, Arvin Iracheta‐Vellve, +63

Nature

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

Xiu Jun Cai, Zhiyu Zhang, Jintao Yuan, +7

Stem Cell Research & Therapy