Gerhard Siemeister

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

J M Wood, Guido Bold, Elisabeth Buchdunger et al. · PubMed · 2000 · 846 citations

Immunology, Oral Administration, Pharmacotherapy +20

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

R.C. Hillig, Brice Sautier, Jens Schroeder et al. · Proceedings of the National Academy of Sciences · 2019 · 363 citations · Full text

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein.

Gerhard Siemeister, Karin Weindel, Katja Mohrs et al. · PubMed · 1996 · 310 citations

Vhl Syndrome, Renal Pathology, Pathology +16

Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.

Bernhard Barleon, Gerhard Siemeister, Georg Martiny‐Baron et al. · PubMed · 1997 · 218 citations

Endothelial Cells, Immunology, Pathology +16

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

Günter Finkenzeller, Angelica Sparacio, Antje Technau et al. · Oncogene · 1997 · 202 citations

Thrombopoiesis, Thrombosis, Proximal Promoter +9