The polycystin complex mediates Wnt/Ca2+ signalling

Seokho Kim, Hongguang Nie, Vasyl Nesin, +8

Nature Cell Biology

Signal TransductionMolecular PhysiologySignaling PathwayMolecular PathwayPolycystin Complex Mediates +6

Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype

Sarah R. Senum, Ying Li, Katherine A. Benson, +25

The American Journal of Human Genetics

UrologyAutoimmune DiseaseMedicineRenal PathologyGenetic Epidemiology +10

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Hyunho Kim, Hangxue Xu, Yao Qin, +11

Nature Communications

A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed

Cheng-Chao Lin, Mahiro Kurashige, Yi Liu, +17

Scientific Reports

Pkd1 and Pkd2 Are Required for Normal Placental Development

Miguel A. García-González, Patricia Outeda, Qin Zhou, +7

PLoS ONE

Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

Patricia Outeda, David L. Huso, Steven A. Fisher, +5

Cell Reports

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease

Liudmila Cebotaru, Qiangni Liu, Murali K. Yanda, +6

Kidney International

ChromatinUrologyActivity ReducesMedicinePathology +6

A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism

Patricia Outeda, Luís F. Menezes, Erum A. Hartung, +9

Kidney International

Novel ModelUrologyFibrosisDisease MechanismMedicine +7

A Novel Pattern of Mutation in Uromodulin Disorders: Autosomal Dominant Medullary Cystic Kidney Disease Type 2, Familial Juvenile Hyperuricemic Nephropathy, and Autosomal Dominant Glomerulocystic Kidney Disease

Xosé M. Lens, Julio Fernandez-Banet, Patricia Outeda, +1

American Journal of Kidney Diseases

Glomerular DiseaseGlomerulonephritisUromodulin DisordersUrologyRenal Disease +11

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology

Jun-Ya Kaimori, Cheng-Chao Lin, Patricia Outeda, +16

Scientific Reports