Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

Tai-An Lin, Kim W. McIntyre, Jagabandhu Das, +23

Biochemistry

Inflammatory Lung DiseaseLung InflammationT-regulatory CellImmunologyImmunologic Mechanism +19

Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors

Jagabandhu Das, Robert V. Moquin, James C. Lin, +10

Bioorganic & Medicinal Chemistry Letters

Potent P56lck InhibitorsMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2

Chunjian Liu, James C. Lin, Charles M. Langevine, +22

Journal of Medicinal Chemistry

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Jagabandhu Das, Joseph A. Furch, Chunjian Liu, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +8

5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

Chunjian Liu, Stephen T. Wrobleski, James C. Lin, +17

Journal of Medicinal Chemistry

5-Cyanopyrimidine DerivativesDrug TargetP38 InhibitorsCellular PharmacologyPharmacotherapy +17

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-<i>N</i>-propylpyrrolo[1,2-<i>f</i>][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases

Chunjian Liu, James C. Lin, Stephen T. Wrobleski, +25

Journal of Medicinal Chemistry

P38α Enzymatic AssayPharmacotherapyInflammatory ArthritisInflammationMolecular Pharmacology +16

Benzothiazole based inhibitors of p38α MAP kinase

Chunjian Liu, James C. Lin, Sidney Pitt, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicinePharmacological AgentPharmacotherapy +4

Identification of Imidazo[1,2-<i>b</i>]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors

Chunjian Liu, James C. Lin, Ryan Moslin, +26

ACS Medicinal Chemistry Letters

Discovery of <i>N</i>-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-<i>N</i>-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity

T. G. Murali Dhar, Zhongqi Shen, Junqing Guo, +20

Journal of Medicinal Chemistry

Potent InhibitorPharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +15

Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases

Qing Shi, Andrew J. Tebben, Alaric J. Dyckman, +18

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryAutoimmune DiseaseMedicineTyrosine Kinase +11