Charles M. Langevine

Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Scott H. Watterson, George V. De Lucca, Qing Shi et al. · Journal of Medicinal Chemistry · 2016 · 142 citations · Full text

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2

Chunjian Liu, James C. Lin, Charles M. Langevine et al. · Journal of Medicinal Chemistry · 2020 · 76 citations · Full text

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment

David S. Weinstein, Wen Liu, Khehyong Ngu et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 53 citations · Full text

Medicinal Chemistry, Human Enzyme, Biochemistry +10

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase

David S. Weinstein, Wen Liu, Zhengxiang Gu et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 51 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase

Khehyong Ngu, David S. Weinstein, Wen Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 32 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +9