Concepedia

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment

David S. Weinstein, Wen Liu, Khehyong Ngu, Charles M. Langevine, Donald W. Combs, Shaobin Zhuang, Cindy Chen, Cort S. Madsen, Timothy W. Harper, Jeffrey A. Robl

Bioorganic & Medicinal Chemistry Letters · 2007 · 53 citations · 10 references

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10

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

Charles N. Serhan, Ashish Jain, Sylvie Marleau et al. · The Journal of Immunology · 2003 · 405 citations

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A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense

Karsten Gronert, Neha Maheshwari, Nabeela Khan et al. · Journal of Biological Chemistry · 2005 · 314 citations · Full text

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12/15-Lipoxygenase Is Increased in Alzheimer's Disease

Domenico Praticò, Victoria Zhukareva, Yuemang Yao et al. · American Journal Of Pathology · 2004 · 242 citations · Full text

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Novel Human Lipoxygenase Inhibitors Discovered Using Virtual Screening with Homology Models

Victor Kenyon, Ilya Chorny, Wendy J. Carvajal et al. · Journal of Medicinal Chemistry · 2006 · 85 citations · Full text

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15-Lipoxygenase and Its Inhibition: A Novel Therapeutic Target for Vascular Disease

Joseph A. Cornicelli, Bharat K. Trivedi · Current Pharmaceutical Design · 1999 · 81 citations

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