Neil S. Renninger

High-level semi-synthetic production of the potent antimalarial artemisinin

Christopher J. Paddon, Patrick J. Westfall, Douglas J. Pitera et al. · Nature · 2013 · 2.1K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Patrick J. Westfall, Douglas J. Pitera, Jacob R. Lenihan et al. · Proceedings of the National Academy of Sciences · 2012 · 725 citations · Full text

Life Sciences, Biochemistry, Biotechnology +15

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

Hiroko Tsuruta, Christopher J. Paddon, Diana G. Eng et al. · PLoS ONE · 2009 · 369 citations · Full text

Life Sciences, Biotechnology, Microbiology +17

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450 _BM3

Jeffrey A. Dietrich, Yasuo Yoshikuni, Karl J. Fisher et al. · ACS Chemical Biology · 2009 · 186 citations · Full text

Life Sciences, Biochemistry, Biotechnology +17

Microbially Derived Artemisinin: A Biotechnology Solution to the Global Problem of Access to Affordable Antimalarial Drugs

Victoria L. Hale, Jay D. Keasling, Neil S. Renninger et al. · American Journal of Tropical Medicine and Hygiene · 2007 · 131 citations · Full text

Life Sciences, Biotechnology, Pharmaceutical Biotechnology +13