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High-level semi-synthetic production of the potent antimalarial artemisinin

Christopher J. Paddon, Patrick J. Westfall, Douglas J. Pitera, Kirsten R. Benjamin, Karl J. Fisher, Derek McPhee, Michael D. Leavell, Anna Tai, A. Denise Main, Diana G. Eng,

Nature · 2013 · 2.1K citations · 24 references

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24

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Dae‐Kyun Ro, Eric M. Paradise, Mario Ouellet et al. · Nature · 2006 · 2.8K citations

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Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

Alan L. Goldstein, John H. McCusker · Yeast · 1999 · 1.9K citations

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Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Patrick J. Westfall, Douglas J. Pitera, Jacob R. Lenihan et al. · Proceedings of the National Academy of Sciences · 2012 · 725 citations · Full text

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Continuous‐Flow Synthesis of the Anti‐Malaria Drug Artemisinin

François Lévesque, Peter H. Seeberger · Angewandte Chemie International Edition · 2012 · 507 citations

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<i>Artemisia annua</i> L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin

Keat H. Teoh, Devin R. Polichuk, Darwin W. Reed et al. · FEBS Letters · 2006 · 412 citations · Full text

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