Diana G. Eng

High-level semi-synthetic production of the potent antimalarial artemisinin

Christopher J. Paddon, Patrick J. Westfall, Douglas J. Pitera et al. · Nature · 2013 · 2.1K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Patrick J. Westfall, Douglas J. Pitera, Jacob R. Lenihan et al. · Proceedings of the National Academy of Sciences · 2012 · 725 citations · Full text

Life Sciences, Biochemistry, Biotechnology +15

Rewriting yeast central carbon metabolism for industrial isoprenoid production

Adam L. Meadows, Kristy Hawkins, Yoseph Tsegaye et al. · Nature · 2016 · 717 citations

Life Sciences, Biochemistry, Microbiology +14

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

Hiroko Tsuruta, Christopher J. Paddon, Diana G. Eng et al. · PLoS ONE · 2009 · 369 citations · Full text

Life Sciences, Biotechnology, Microbiology +17

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

Dae‐Kyun Ro, Mario Ouellet, Eric M. Paradise et al. · BMC Biotechnology · 2008 · 196 citations · Full text

Pharmacy, Biochemistry, Biotechnology +17