Kathleen M. Frey

Predicting resistance mutations using protein design algorithms

Kathleen M. Frey, Ivelin S. Georgiev, Bruce R. Donald et al. · Proceedings of the National Academy of Sciences · 2010 · 124 citations · Full text

Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group

Won-Gil Lee, Ricardo Gallardo‐Macias, Kathleen M. Frey et al. · Journal of the American Chemical Society · 2013 · 124 citations · Full text

Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles’ Heel of Targeted Therapy

Christal D. Sohl, Molly R. Ryan, BeiBei Luo et al. · ACS Chemical Biology · 2015 · 70 citations · Full text

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Kathleen M. Frey, Jieying Liu, Michael N. Lombardo et al. · Journal of Molecular Biology · 2009 · 57 citations · Full text

Antimicrobial Resistance Gene, Biochemistry, Trimethoprim Resistance +8

Protein design algorithms predict viable resistance to an experimental antifolate

Stephanie M. Reeve, Pablo Gaínza, Kathleen M. Frey et al. · Proceedings of the National Academy of Sciences · 2014 · 52 citations · Full text