Michael N. Lombardo

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Kathleen M. Frey, Jieying Liu, Michael N. Lombardo et al. · Journal of Molecular Biology · 2009 · 57 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

Propargyl-Linked Antifolates are Dual Inhibitors of <i>Candida albicans</i> and <i>Candida glabrata</i>

Narendran G-Dayanandan, Janet L. Paulsen, Kishore Viswanathan et al. · Journal of Medicinal Chemistry · 2014 · 53 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates

Michael B. Cammarata, Ross Thyer, Michael N. Lombardo et al. · Chemical Science · 2017 · 53 citations · Full text

Life Sciences, Genetics, Microbiology +13

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase

Kathleen M. Frey, Michael N. Lombardo, Dennis L. Wright et al. · Journal of Structural Biology · 2009 · 47 citations

Life Sciences, Infectious Diseases, Microbiology +14

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates

Michael N. Lombardo, Narendran G-Dayanandan, Dennis L. Wright et al. · ACS Infectious Diseases · 2015 · 43 citations

Life Sciences, Molecular Biology, Pharmacology +17