Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Guo Zhang, Juxue Li, Sudarshana Purkayastha, +6

Nature

AgingStress HormonePhysiologyNeuroendocrine MechanismHypothalamic Programming +4

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

Juxue Li, Yizhe Tang, Dongsheng Cai

Nature Cell Biology

ObesityMetabolic SyndromeNeurodegenerative DiseasesNeurodegenerative MechanismEnergy Homeostasis +10

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

Yizhe Tang, Izumi Horikawa, Masahiko Ajiro, +6

Oncogene

Cell RegulationSpliced IsoformCellular SenescenceTumor SuppressorSystems Biology +2

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

Jingqi Yan, Hai Zhang, Ye Yin, +5

Nature Medicine

ObesityMetabolic SyndromeSystems BiologyDevelopmental BiologyDiabetes +7

Directing adenovirus across the blood–brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model

Yizhe Tang, Tian Han, Maaike Everts, +4

Gene Therapy

Blood–brain BarrierVitro ModelImmunologyEndocytic PathwayAntiviral Response +8

HIV Antigen Incorporation within Adenovirus Hexon Hypervariable 2 for a Novel HIV Vaccine Approach

Qiana L. Matthews, Aiman Fatima, Yizhe Tang, +11

PLoS ONE

Hiv Antigen IncorporationAd VirionImmunologyViral Structural ProteinImmunotherapy +14

Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus

Juxue Li, Yizhe Tang, Sudarshana Purkayastha, +2

Molecular Metabolism

Insulin SignalingObesityMetabolic SyndromeHypothalamic PeptideMetabolic Signaling +20

ASPM Is a Prognostic Biomarker and Correlates With Immune Infiltration in Kidney Renal Clear Cell Carcinoma and Liver Hepatocellular Carcinoma

Tingting Deng, Yang Liu, Jialang Zhuang, +2

Frontiers in Oncology

Surface protein profiling and subtyping of extracellular vesicles in body fluids reveals non‐CSF biomarkers of Alzheimer's disease

You Cai, Ting Chen, Yanling Cai, +8

Journal of Extracellular Vesicles

Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IX

Yizhe Tang, Long P. Le, Qiana L. Matthews, +3

Virology

Virus StructureViral ReplicationNatural SciencesPathogenesisImmunology +8