c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Omid Vafa, Mark Wade, S Kern, +4

Molecular Cell

Dna DamageCell RegulationOncogenic AgentMedicineCell Death +7

Engineered antibody Fc variants with enhanced effector function

Greg A. Lazar, Wei Dang, Sher Karki, +11

Proceedings of the National Academy of Sciences

Engineered Fc RegionsNovel TherapyAntibody Fc VariantsMedicineImmunology +11

Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres

Peter E. Warburton, Carol Cooke, Sylvie Bourassa, +9

Current Biology

p53 stabilization is decreased upon NFκB activation

Vinay Tergaonkar, Matthew P. Pando, Omid Vafa, +2

Cancer Cell

Cell RegulationCell DeathTumor SuppressorMedicineCell Biology +3

Assembly of CENP-A into Centromeric Chromatin Requires a Cooperative Array of Nucleosomal DNA Contact Sites

Richard D. Shelby, Omid Vafa, Kevin F. Sullivan

The Journal of Cell Biology

Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants

Paul M. Steed, Malú G. Tansey, Jonathan Zalevsky, +31

Science

ImmunologyCell DeathPathologyImmunologic MechanismImmunotherapy +16

Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α

David J. Shealy, Ann Cai, Kim Staquet, +16

mAbs

ImmunologyImmune RegulationPathologyImmunologic MechanismImmunotherapeutics +20

Chromatin containing CENP-A and α-satellite DNA is a major component of the inner kinetochore plate

Omid Vafa, Kevin F. Sullivan

Current Biology

ChromatinChromosome DynamicsChromatin StructureCell DivisionMajor Component +13

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

Omid Vafa, Gary L. Gilliland, Randall J. Brezski, +7

Methods

Engineered Fc VariantSignal TransductionAutoimmune DiseaseImmune Effector FunctionsStructural Perturbations +10

Micromanipulation of sperm by a laser generated optical trap

Yona Tadir, W. H. Wright, Omid Vafa, +3

Fertility and Sterility

EngineeringMicroscopyLaser Micro-processingMicrofabricationMicromanipulation +5