David Wildes

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Robert J. Nichols, Franziska Haderk, Carlos Stahlhut et al. · Nature Cell Biology · 2018 · 418 citations

Medicine, Molecular Biology, Oncology +16

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Matthew Holderfield, Bianca J. Lee, Jingjing Jiang et al. · Nature · 2024 · 318 citations · Full text

Medicine, Oncology, Pharmacology +16

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Jingjing Jiang, Lingyan Jiang, Benjamin J. Maldonato et al. · Cancer Discovery · 2024 · 281 citations · Full text

Medicine, Oncology, Pharmacology +17

Protein folding: Defining a “standard” set of experimental conditions and a preliminary kinetic data set of two‐state proteins

Karen L. Maxwell, David Wildes, Arash Zarrine‐Afsar et al. · Protein Science · 2005 · 236 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

Christopher J. Schulze, Kyle J. Seamon, Yulei Zhao et al. · Science · 2023 · 232 citations · Full text

Medicine, Medicinal Chemistry, Oncology +17