Nagasree Chakka

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Howard Bregman, Nagasree Chakka, Angel Guzmán-Pérez et al. · Journal of Medicinal Chemistry · 2013 · 76 citations · Full text

Drug Target, Selective Tankyrase Inhibitors, Pharmacotherapy +20

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na_V1.7 Inhibitors

Erin F. DiMauro, Stephen M. Altmann, Loren Berry et al. · Journal of Medicinal Chemistry · 2016 · 42 citations · Full text

Medicinal Chemistry, Representative Lead 36, Biochemistry +13

Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Zihao Hua, Howard Bregman, John L. Buchanan et al. · Journal of Medicinal Chemistry · 2013 · 41 citations · Full text

Compound 8, Pharmaceutical Science, Tool Compounds +17

Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors

Zaihui Zhang, Kodumuru Vishnumurthy, Serguei Sviridov et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 36 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Pharmaceutical Chemistry +10

Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome

Zaihui Zhang, Shaoyi Sun, Kodumuru Vishnumurthy et al. · Journal of Medicinal Chemistry · 2012 · 29 citations · Full text

Obesity, Metabolic Syndrome, Lipid Synthesis +12