Hamilton B. Bennett

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

Michael P. Clark, Mark W. Ledeboer, Ioana Davies et al. · Journal of Medicinal Chemistry · 2014 · 207 citations · Full text

Influenza Pb2, Medicinal Chemistry, Medicine +13

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

Randal A. Byrn, Steven J.M. Jones, Hamilton B. Bennett et al. · Antimicrobial Agents and Chemotherapy · 2014 · 185 citations · Full text

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

Upul K. Bandarage, Michael P. Clark, Emanuele Perola et al. · ACS Medicinal Chemistry Letters · 2017 · 48 citations · Full text

Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors

Michael J. Boyd, Upul K. Bandarage, Hamilton B. Bennett et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 31 citations · Full text

Drug Candidate Vx-787, Medicinal Chemistry, Biochemistry +11

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2

Luc J. Farmer, Michael P. Clark, Michael J. Boyd et al. · ACS Medicinal Chemistry Letters · 2017 · 25 citations · Full text