K.W. Nettles

Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism

John B. Bruning, Michael J. Chalmers, Swati Prasad et al. · Structure · 2007 · 383 citations · Full text

Molecular Pharmacology, Molecular Physiology, Signal Transduction +7

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

Andrew K. Shiau, D. Barstad, James T. Radek et al. · Nature Structural Biology · 2002 · 354 citations

Structural Characterization, Signal Transduction, Functional Selectivity +11

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

Yuechao Zhao, Ping Gong, Yiru Chen et al. · Science Translational Medicine · 2015 · 162 citations · Full text

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

K.W. Nettles, John B. Bruning, Germán A. Gil et al. · Nature Chemical Biology · 2008 · 161 citations · Full text

Signal Transduction, Biochemistry, G Protein-coupled Receptor +11

Coupling of receptor conformation and ligand orientation determine graded activity

John B. Bruning, A.A. Parent, Germán A. Gil et al. · Nature Chemical Biology · 2010 · 140 citations · Full text

Signal Transduction, Receptor Conformation, Biochemistry +10