K.W. Nettles

Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism

John B. Bruning, Michael J. Chalmers, Swati Prasad et al. · Structure · 2007 · 387 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

Andrew K. Shiau, D. Barstad, James T. Radek et al. · Nature Structural Biology · 2002 · 356 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

Yuechao Zhao, Ping Gong, Yiru Chen et al. · Science Translational Medicine · 2015 · 166 citations · Full text

Medicine, Endocrinology, Gynecology +13

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

K.W. Nettles, John B. Bruning, Germán A. Gil et al. · Nature Chemical Biology · 2008 · 161 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Coupling of receptor conformation and ligand orientation determine graded activity

John B. Bruning, A.A. Parent, Germán A. Gil et al. · Nature Chemical Biology · 2010 · 142 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14