Christine Gardiner

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess et al. · ACS Medicinal Chemistry Letters · 2010 · 372 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models

Phillip C.C. Liu, Holly K. Koblish, Liangxing Wu et al. · PLoS ONE · 2020 · 161 citations · Full text

Medicine, Oncology, Pharmacology +14

The Janus Kinase 2 Inhibitor Fedratinib Inhibits Thiamine Uptake: A Putative Mechanism for the Onset of Wernicke’s Encephalopathy

Qiang Zhang, Yan Zhang, Sharon Diamond et al. · Drug Metabolism and Disposition · 2014 · 121 citations

Medicine, Pharmacology, Pharmacotherapy +14

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors

Jesús R. Medina, Christopher Becker, Charles W. Blackledge et al. · Journal of Medicinal Chemistry · 2011 · 54 citations · Full text

Pharmacy, Oncology, Pharmacology +13

The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies

Matthew C. Stubbs, Timothy C. Burn, Richard Sparks et al. · Clinical Cancer Research · 2018 · 49 citations

Medicine, Oncology, Pharmacology +16